Because MS patients have variable clinical courses and disease severities, it is important to identify biomarkers that predict disease activity and severity. Multiple sclerosis (MS), the most prevalent inflammatory disease of the central nervous system (CNS), is characterized by damaged to myelin sheaths and oligodendrocytes.
4Department of Neurology, Brain and Nerve Center, Fukuoka Central Hospital, International University of Health and Welfare, Fukuoka, Japan. 
3Translational Neuroscience Center, Graduate School of Medicine, School of Pharmacy at Fukuoka, International University of Health and Welfare, Fukuoka, Japan. 2Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan. 1Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Yukino Miyachi 1 †, Takayuki Fujii 1 †, Ryo Yamasaki 1, Daisuke Tsuchimoto 2, Kyoko Iinuma 1, Ayako Sakoda 1,3,4, Shoko Fukumoto 1, Takuya Matsushita 1, Katsuhisa Masaki 1, Noriko Isobe 1, Yusaku Nakabeppu 2 and Jun-ichi Kira 1,3,4 *
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